Dr. Jun Fang, Associate Professor

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan

Biography

Dr. Jun Fang graduated with a degree in medicine from Bethune Medical University (Jilin University's Faculty of Medicine) in 1995. He completed his master's degree in thoracic surgery at China Medical University in 1998 and then pursued his Ph.D. in Medicine at Kumamoto University's in 2003. From 2003 to 2005, Fang worked as a Research Associate at Duke University Medical Center in the United States. In 2005, he joined Sojo University's Faculty of Pharmaceutical Sciences. Since 2016, he has been a visiting professor at the School of Public Health, Anhui Medical University (China). For many years, he has conducted research on the EPR effect and anticancer and anti-inflammatory nanomedicine. From 2014 to 2017, he was selected as a Highly Cited Researcher in the field of Pharmacology and Toxicology. He was also included in the 2023 global ranking of scholars with Lifetime Academic Influence. In the past decade, he published 130 papers, with a cumulative impact factor (IF) exceeding 700. These papers have been cited over 10,000 times in SCI-source journals, with the highest citation count for a single paper being over 4,800 times.

Topic

Development of a Polymer Micelle-based Carbon Monoxide Delivery System for Inflammation and Cancer Treatment

Abstract

Remote sensing technology is an important technical means for human beings to perceive the world, and hyperspectral image classification technology has become the mainstream of current research. Hyperspectral image classification (HSIC) is a pixel-level classification task, which is mainly used for fine extraction and recognition of ground object information. HSIC is the basis for subsequent practical application tasks of hyperspectral images and has very important research significance, which is widely used in digital precision agriculture, environmental monitoring, national defense and military strategy and other fields. With the rapid development of artificial intelligence technology, many new hyperspectral image classification methods and algorithms have been proposed. Moreover, rapid advances in these methods have also promoted the application of associated algorithms and techniques to problems in many related fields. This keynote aims to report and cover the latest advances and trends about the Deep Learning Methods for Hyperspectral Image Classification.

Dr. Xiaochong Jian, Professor

School of Stomatology, Hainan Medical University, Haikou, China

Biography

Dr. Xiaochong Jian is a professor at the School of Stomatology, Hainan Medical University. He received his doctorate degree from Hainan Medical University in 2017. He has published more than 10 papers and obtained 26 patents. He has participated in the translation of two professional books and was an editorial board member of oral and maxillofacial surgery. He is good at implant surgery and has implanted more than 10,000 teeth. He often conducts live surgery broadcasts and implant training. He is a senior lecturer for multiple implant brands.

Topic

Application of Inferior Alveolar Nerve Lateralization in Conjunction with Implant Placement

Abstract

One of the most common challenges for implant placement is insufficient bone height and volume. Installing implants without encroaching on the inferior alveolar nerve is nearly impossible, especially in patients with atrophic edentulous posterior mandibles. Several treatment options that do not interfere with the nerve canal have been suggested: vertical ridge augmentation, distraction osteogenesis, guided bone regeneration, In more severe cases, another option is inferior alveolar nerve transposition. In contrast, the inferior alveolar nerve transposition can install longer implants and improve the success rate, Reduce the amount of bone grafting and avoid bone removal complications; is simpler and easier than distraction, with lower treatment cost and shorter cycle. The authors made some improvements to the surgical operation, making it easier to master and with fewer complications.

Dr. Jing Du, Professor

Beijing Anding Hospital, Capital Medical University, Beijing, China

Biography

Dr. Jing Du is a professor in Beijing Anding Hospital affiliated to Capital Medical University in Beijing, China. In Beijing Anding Hospital, she is engaged in the research of cellular and molecular pathophysiology and neuropsychopharmacology of mental diseases such as depression, anxiety, autism and schizophrenia. She was formerly a staff scientist at the National Institute of Mental Health of the National Institutes of Health(NIH) in USA. She has won many awards, including the NIH Performance Award in Recognition and Appreciation of Special Achievement issued by the National Institutes of Health. She is a Full member of the American College of Neuropsychopharmacology (ACNP). She has published 64 SCI articles in the field of neuropsychopharmacology. Her H index is 35. She is recognized nationally and internationally for her research contributions and achievements in psychopharmacology.

Topic

Nuclear Receptors Modulate Inflammasomes in the Pathophysiology and Treatment of Major Depressive Disorder

Abstract

Major depressive disorder is a common, chronic and recurrent disease. Existing drugs are ineffective to one third of patients, so it is urgent to develop novel and rapid antidepressants. Accumulative evidence has shown that immune inflammation, particularly inflammasome activity, plays an important role in the pathophysiology of MDD. We summarize the evidence on nuclear receptors (NRs), such as glucocorticoid receptor, vitamin D receptor, estrogen receptor, aryl-hydrocarbon receptor, and peroxisome proliferator-activated receptor(PPARs), in modulating the inflammasome activity and depression-associated behaviors. Chronic Social Defeat Stress (CSDS) depressed mice reduced the expression level in prefrontal cortex (PFC) of farnesoid X receptor(FXR), which is a nuclear receptor activated by CDCA. We found that CDCA treatment restored the level of FXR in the CSDS mice, decreased the activity of the NLRP3 inflammasome and caspase-1 and subsequently showed antidepressant effects in the tests of sucrose preference, tail suspension, and forced swimming in CSDS mouse model of depression. Moreover, we also found that ganoderic acid A (GAA) modulated CDCA receptor FXR, inhibited brain inflammatory activity, and showed antidepressant effects in the chronic social defeat stress depression model, tail suspension, forced swimming, and sucrose preference tests. GAA directly inhibited the activity of the NLRP3 inflammasome, and activated the synaptic AMPA by regulating FXR in the PFC of mice. If we knocked out FXR or injected the FXR-specific inhibitor z-gugglesterone (GS), the antidepressant effects induced by GAA were completely abolished. Proteomic analysis identified distinct proteins in CSDS (305), GAA-treated (949), and IMI-treated (289) groups. Enrichment in mitochondrial and synaptic proteins was evident from GO and PPI analyses. PRM analysis revealed significant expression changes in proteins crucial for mitochondrial and synaptic functions (namely, Naa30, Bnip1, Tubgcp4, Atxn3, Carmil1, Nup37, Apoh, Mrpl42, Tprkb, Acbd5, Dcx, Erbb4, Ppp1r2, Fam3c, Rnf112, and Cep41). Western blot validation in the prefrontal cortex showed increased levels of Mrpl42, Dcx, Fam3c, Ppp1r2, Rnf112, and Naa30 following GAA treatment. In another independent study, we found that oridonin significantly enhanced the expression of nuclear receptor PPAR-γ, GluA1 (Ser845) phosphorylation, GluA1 in the total protein extract of the prefrontal cortex (PFC), and showed antidepressant efficacy. Blocking nuclear receptor PPAR-γ was able to block antidepressant effects of oridonin. These studies demonstrate that nuclear receptor signaling regulates neuroimmune and antidepressant behaviors and is potential targets for the treatment of MDD.

Dr. Jinhui Wang, Associate Professor

Institute of Drug Discovery Technology, Ningbo University, Ningbo, China

Biography

Dr. Jinhui Wang is now an associate professor at Ningbo University. In 2014, he was assigned to the University of Toulouse III, France, to pursue a doctorate in metal-organic chemistry and coordination chemistry, under the guidance of Professor Eric Benoist, dedicated to the application of metal-organic complexes in biological imaging research; In 2018, he was introduced to Ningbo University as an outstanding doctor and served as an assistant researcher. His research focuses on Cancer Imaging, Polymer Characterization, Polymerization Nano Drug Delivery and Nanotechnology for Drug Delivery.

Topic

Engineering of Phosphatidylserine-targeting ROS-responsive Polymeric Prodrug for the Repair of Ischemia-reperfusion-induced Acute Kidney Injury

Abstract

Ischemia-reperfusion-induced acute kidney injury (IR-AKI) commonly occurs in situations such as hemorrhagic shock, kidney transplantation, and cardiovascular surgery. In this study, we developed an ROS-responsive polymeric prodrugs (Zn-D/DTH) which could target the externalized PS of apoptotic cells, and then responsively released HDM (anti-inflammatory peptides) in the presence of intracellular ROS. Zn-D/DTH effectively ameliorated renal function and mitigated pathological alterations such as the loss of the brush border, tubular dilation, and accumulation of cellular debris within the tubular lumens. Furthermore, Zn-D/DTH greatly reduced the generation of pro-inflammatory factors like IL-6, COX-2, and iNOS in renal tissues, suggesting its protective role largely stems from suppression of the inflammatory response. Additional mechanism exploration revealed that Zn-D/DTH markedly decreased the expression levels of TLR4 and MyD88, as well as the phosphorylation of NF-κB in the damaged kidneys. This, in turn, reduced the number of apoptotic tubular cells and the activity of Caspase 9 and Caspase 3 caused by ischemia-reperfusion. Additionally, Zn-D/DTH treatment showed improvement in the long-term renal damage and fibrosis induced by ischemia-reperfusion. The experimental outcomes indicated that Zn-D/DTH attenuated renal ischemia-reperfusion injury and delayed the transition from acute kidney injury to chronic kidney disease by downregulating the TLR4/MyD88/NF-κB signaling pathway and reducing the expression of apoptotic caspases, thereby inhibiting inflammation and reducing cell apoptosis.